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Hypoparathyroidism Stem Cell Consortium Grant Program

Grant to a USA, Canada, and International Research Team
to Develop a Therapy to Treat Hypoparathyroidism

Agency Type:

Foundation / Corporation

Funding Source:

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University of Pennsylvania School of Medicine - Orphan Disease Center (ODC) and Hypopara Research Foundation

LOI Date:

09/09/19

Deadline Date:

10/09/19 8:00 PM EST

Description:

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Grant to a USA, Canada, or International multidisciplinary team at an IHE to research and develop long-term, effective therapies to treat hypoparathyroidism. Applicants must submit a letter of interest prior to applying. Funding is intended to cover the laboratory, salary, and other expenses involved in conducting this research.

The Orphan Disease Center, in collaboration with the Hypopara Research Foundation, is seeking grant applications from multidisciplinary teams of scientists that aim to develop a potential long-term therapy for hypoparathyroidism, by using advances in stem cell research to regenerate and transplant parathyroid glands. The Foundation expects these research efforts will focus on the biology of parathyroid cell differentiation, although the overall effort must be directed to the longer range goal of developing human treatments. The Foundation is flexible regarding the specific goals of the applications although the following areas of research could be considered:

  1. Identification of parathyroid cell markers. Identifying and validate parathyroid cell or precursor markers.
  2. Development of a stem cell differentiation protocol to convert ES cells or iPSCs to functioning parathyroid cells. Development of a reproducible protocol for differentiation of pluripotent stem cells into parathyroid cells or precursor cells. Creation of a cell line/organoid that can be induced to produce and secrete parathyroid hormone. The cells/organoids should produce parathyroid hormone production in response to calcium levels.
  3. Development of transplantation methods that lead to long-term engraftment of parathyroid cells.
  4. Demonstration of physiologic regulation of parathyroid hormone production from transplanted cells in an animal model. 

Allowable direct costs:

  • Salary for PI
  • Salary/stipend and related benefits for graduate student/postdoctoral fellow/technical support
  • Travel (up to $1500)
  • Laboratory supplies and other research expenses
  • IDCs of 10% are included in the total award amount

GrantWatch ID#:

GrantWatch ID#: 186674

Estimated Total Program Funding:

$1,000,000

Number of Grants:

1

Estimated Size of Grant:

Grant will provide up to $1,000,000, with each year of funding up to $500,000.

Term of Contract:

Grants will cover a two year period. Grantees must apply for renewal for the second year of funding two months prior to the end of the first year of the grant. As such, each year will be treated as an individual grant award.

Additional Eligibility Criteria:

All individuals holding a faculty-level appointment at an academic institution or a senior position at a nonprofit institution or foundation are eligible to respond to this RFA.

Biopharmaceutical companies are not eligible to apply, however subcontracts to commercial entities will be allowed if they provide unique research capabilities.

All members of the consortium should provide key technical/scientific contributions. It is an advantage for consortium members to have a track record of collaboration.

Unallowable costs:
- Consultant costs
- Tuition
- Professional membership dues
- Equipment >$5,000
- General office supplies, institutional administrative charges (e.g., telephone, other electronic communication, IT network, etc.)
- Pre‐award charges
- Any other expenses not directly related to the project

Pre-Application Information:

The one-page LOI is due no later than Monday, September 9, 2019 by 8:00 PM (EST).

Note: Full Application is by invitation only after review of Pre-Application.

Proposal Due Date: Wednesday, October 9, 2019 by 8:00 PM (EST)

Funds will be issued through a cost reimbursement mechanism executed by purchase order from the University of Pennsylvania.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Submit LOI Online:
https://orphandiseasecenter.submittable.com/submit/144123/2019-hypoparathyroidism-stem-cell-consortium-pilot-grant-program-loi

For any administrative inquiries regarding this grant, please contact Samantha Charleston at scharle@upenn.edu or 215-573-6822.

For any scientific inquiries regarding this grant, please email Sheridan Carrington, PhD at sjcarr@upenn.edu.

URL for Full Text (RFP):

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International country outside of the USA, Israel and Canada.

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